Scientists in the 1930s, using machines that could break apart the nuclear cores of atoms, confirmed Einstein's formula E=mc² . The release of energy in a nuclear transformation was so great that it could cause a detectable change in the mass of the nucleus. But the study of nuclei -- in those years the fastest growing area of physics -- had scant effect on Einstein. Nuclear physicists were gathering into ever-larger teams of scientists and technicians, heavily funded by governments and foundations, engaged in experiments using massive devices. Such work was alien to Einstein's habit of abstract thought, done alone or with a mathematical assistant. In return, experimental nuclear physicists in the 1930s had little need for Einstein's theories.
arie 
klodowska 
urie discovered the mysterious element radium. It opened the door to deep changes in the way scientists think about matter and energy. She also led the way to a new era for medical knowledge and the treatment of diseases.
